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Developing a canine model of idiopathic epilepsy.


Idiopathic epilepsy (IE) is the most common inherited neurological condition in people and dogs. The genetic basis of rare monogenic forms of IE have been identified in genetically isolated human populations, but the most common forms of IE epilepsy in people are polygenic and the molecular bases have not yet been elucidated. Due to inbreeding practices in dogs the individual breeds resemble the population dynamics of genetically isolated human populations, and therefore the dog may represent a good model to help define the molecular bases of IE, and novel therapies for IE.