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Variability in CYP3A expression and metabolism: Influence of genetics and probe substrate selection.


Considerable effort has been directed to the study of one of the main drug metabolizing enzyme subfamilies, cytochrome P450 3A (CYP3A). The main adult isoforms, CYP3A4 and CYP3A5, are found in liver and small intestine where they contribute to the systemic and oral clearance of many drugs. Although large interindividual differences in CYP3A-mediated drug metabolism have been noted, the biological basis for this interindividual variability is not well understood.