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Cardiac Drug Safety

A Bench to Bedside Approach


At present, over 120 medications have been withdrawn from the major global pharmaceutical markets due to potentially lethal unwanted effects on the heart, namely ventricular fibrillation. With recent FDA guidelines recommending stringent testing of new pharmaceuticals on the heart, the importance of cardiac electrophysiology is affecting an increasing number of professionals in a range of industries. This book will equip readers with a clear and solid foundation in the fundamentals of electrophysiology and pharmacology of the heart, explore clinical disorders and treatments and relate this to the research and development of new medicines.Representing an integrative bench to bedside approach to understanding this critical drug safety phenomenon, this book begins with a comprehensive review of the mechanisms responsible for drug-induced arrhythmia, followed by an in-depth discussion of the current preclinical and clinical recording techniques. Additionally, a complete assessment of current methods to stratify cardiac risk in drug development is included. Most importantly, the book develops and outlines the novel strategies and key frameworks that increase the cardiac drug safety and drive down the risk of novel biopharmaceutical products in the future. Contents: Physiology of the Heart; Introduction to Electrophysiology: History, Ion Channels, Important Concepts; Electrophysiology of the Heart; Studying Cardiac Electrophysiology in the Laboratory and Clinic; Electrical Disorders of the Heart: From Cell to Bedside; The Impact of Cardiac Electrophysiology on Drug Development: History, Current Tests (Regulations, Requirements) and Their Shortcomings; Case Studies; The Future of Cardiac Drug Safety: Strategies to Reduce Risk and Ensure Continued Safety.

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