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Evolutionary and epidemic potential of dengue viruses.


The epidemiology of infectious diseases caused by RNA virus is largely determined by the evolutionary potential of this kind of agents, characterized by high mutation rates and occasional exchange of genomic segments between strains. Dengue virus (DENV), one of such rapidly evolving viruses, has emerged as the most extended vector-borne viral pathogen in the world in the last decades. In this study, the forces shaping DENV evolution were investigated in the laboratory and in a natural population.