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Effect of sorbed water on the efficiency of super disintegrants: Physical and mechanistic considerations.


Description

Optimizing the use of the super disintegrants (SD) requires a better understanding of their mechanism of action than currently exists. Because their functionality is fundamentally related to the ability to draw liquid into tablet matrices, it was hypothesized that higher initial moisture contents from sorbed water would decrease their ability to effect rapid disintegration. In testing this hypothesis, a device that automatically measures disintegration time was designed and constructed, sensitive tests to evaluate disintegrant efficiencies were developed, and the mechanisms of action of SDs were studied by relating several physical changes caused by sorbed moisture to their ability to disintegrate tablets.