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Evaluating cornification in the dog by characterizing canine transglutaminase I and defining the clinical, histologic and morphometric features of normal, thyroxine- treated hypothyroid and untreated hypothyroid dogs.


Cornification is the process in which epithelial cells, called keratinocytes, mature to form the life-sustaining outer-most layer of the skin, the stratum corneum, and several components of the hair follicle including the hair shaft. Although cornification is a complex and highly regulated process, it always requires three elements: (1) structural proteins such as keratins, keratin-associated proteins, and the proteins that form the cell envelope, (2) lipids which act as a glue to aid in annealing proteins and (3) the action of enzymes known as transglutaminases that cross-link proteins and stabilize cell membranes.